Self-Assembled Mannan Nanogel: Cytocompatibility and Cell Localization
نویسندگان
چکیده
منابع مشابه
Self-assembled mannan nanogel: cytocompatibility and cell localization.
Amphiphilic mannan, produced by the Michael addition of hydrophobic 1-hexadecanethiol to vinyl methacrylated mannan, self-assembles in aqueous medium through hydrophobic interactions among alkyl chains. Resultant nanogel is stable, spherical, polydisperse, with 50-140 nm mean hydrodynamic diameter depending on the polymer degree of substitution, and nearly neutral negative surface charge. No cy...
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The mechanisms associated with the cellular internalization of nanomedicines must be carefully considered when designing drug- and vaccine-delivery systems. The cellular fate and effects of nanomedicines depend to a large extent on the cell uptake routes. A self-assembled mannan nanogel is developed as a vaccination platform for antigen and adjuvant delivery. The mannan nanogel uptake by murine...
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ژورنال
عنوان ژورنال: Journal of Biomedical Nanotechnology
سال: 2012
ISSN: 1550-7033
DOI: 10.1166/jbn.2012.1408